Pseudo-static slope stability procedures are often employed to evaluate the seismic performance of slope systems, at least in the initial evaluation stages. To yield meaningful results, these methods should rely on parameters that are representative of the existing seismic demand and the properties of the slope system being evaluated. This study proposes a performance-based probabilistic procedure to estimate the seismic pseudo-static coefficient (SPC) in a rational and transparent manner. The procedure has its cornerstone on the evaluation of seismically-induced displacement (D) hazard curves, and it provides SPC estimates that are consistent with the allowable D level that a slope system can sustain, the properties of the sliding mass, the seismic demand at the slope site, and the hazard design level or return period. The proposed procedure can be applied to evaluate the seismic performance of a wide range of slope systems potentially affected by earthquakes from different tectonic settings (i.e. subduction and shallow crustal earthquakes), and has been implemented in a computational platform that facilitates its straightforward use in engineering practice. The implementations are fully automated for South America (i.e., Peru, Chile, Ecuador), Mexico, and the United States, but the proposed framework can be applied worldwide. Finally, an illustrative example for the application of the procedure in the seismic stability assessment of a slope system is provided.